[7][8][9]
Med Rehabil, 2007, 88(2):142—149.
Morone G, Bragoni M, Iosa M, et al. Who may benefit from robotic-assisted gait training? A randomized clinical tri-al in patients with subacute stroke[]]. Neurorehabil Neural Repair, 2011, 25(7):636644.
Bemhard G, Brendan A, Gert P. Brain-Computer Interfaces: Revolutionizing Human-Computer Interaction[M].Springer Ber-lin Heidelberg, 2010.1:127.
Burdea GC, Virtual rehabilitation--benefits and challenges[J], Methods Inf Med, 2003, 42(5):519523.
[10]
Sveistrup H. Motor rehabilitation using
g virtual reality[], J
Neuroeng Rehabil, 2004, 1(1):10.
French B, Thomas LH, Leathley MJ, et al. Repetitive task[11]
training for improving functional
ability after stroke[].
Stroke, 2009, (40):e98—e99
Rizzo A,, Kim G. A SWOT analysis of the field of virtu-
[12][13]
[14][15]
[16]
al reality rehabilitation and therapy[J]. Presence, 2005,14(2): 119146.
Katz N, Ring H, Naveh Y, et al. Interactive virtual environ-ment training for safe street crossing of right hemisphere stroke patients with unilateral spatial neglect[]. Disabil Re-habil, 2005,27(20):12351243
e ae e ada ticity during constraint-induced movement therapy in stroke patients[J]. Neurosci Lett, 1998, 250(1):5—8.
You SH, Jang SH, Kim YH, et al. Virtual reality-induced cortical reorganization and associated locomotor recovery in chronic stroke: an experimenter- blind randomized study[] Stroke, 2005, 36(6):1166—1171.
Holden MK, Dyar T. Virtual environment training: a new tool for neurorehabilitation[J]. Neurology Report, 2002, 26(2):6271.
[][18][19][20]
[21][22][23]
[24[25]
中国庙复医学案志
2014年，第29卷，第3期
Merians AS, Poizner H, Boian R, et al. Sensorimotor train-ing in a virtual reality environment: does it improve func-tional recovery poststroke?[J]. Neurorehabil Neural Repair, 2006, 20(2):252—267.
Jack D, Boian R, Merians AS, et al. Virtual reality-en-hanced stroke rehabilitation[J]. IEEE Trans Neural Syst Re-habil Eng, 2001, 9(3):308—318.
Gaggioli A, Morganti F, Walker R, et al. Training
with
computer-supported motor imagery in post-stroke rehabilita-tion[]. Cyberpsychol Behav, 2004, 7(3):327—332.
Adamovich SV, Fluet GG, Mathai A, et al. Design of a complex virtual reality simulation to train finger motion for persons with hemiparesis: a proof of concept study[]
J Neuroeng Rehabil, 2009, (6):28.
Chilingaryan G, et al.
Subramanian SK, Lourengo CB,
Arm motor recovery using a virtual reality intervention in chronic stroke: randomized control trial[J]. Neurorehabil Neural Repair, 2013, 27(1):13—23.
Lennon S, Baxter D, Ashbum A. Physiotherapy based
on
the Bobath concept in stroke rehabilitation: a survey within the UK[J]. Disabil Rehabil, 2001, 23(6):254—262.
Nudo RJ,Wise BM, SiFuentes F,et al. Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct[J]. Science, 1996, 272(5269):1791 1794.
Hlustik P, Solodkin A, Noll DC, et al.
Cortical plasticity
during three- week motor skill leaming[J]. J Clin Neuro-physiol, 2004, 21(3):180—191.
Adamovich S, Fluet GG, Merians AS, et al. Recovery of hand function in virtual reality: Training hemiparetic hand Bg[aaae Med Biol Soc, 2008, (2008):3475—3478.
·综述·
血液中脑源性神经生长因子与疾病和运动的关系王尊王磊王形23
脑源性神经生长因子(brain derived ncurotrophic fac-tor，BDNF)是体内含量最高的生长因子之一，在人体中枢神经系统和血液中都有一定表达。人体神经系统和血液 BDNF水平与许多神经系统疾病包括抑郁、阿尔茨海默病、精神分裂症及脑损伤和脊髓损伤功能恢复有关"，BDNF还可以影响物质代谢和能量消耗，与糖尿病发生发展相关。运 DOI:10.3969/j.issn.1001-1242.2014.03.026
动可以影响神经系统和血液中BDNF的含量，从而在上述疾病的康复治疗中产生作用。BDNF联系了运动、神经功能和能量物质代谢，因此具有重要意义。本文主要总结血液中 BDNF水平与运动和疾病的关系，以便更深入的探讨运动在这些疾病康复中的分子机制。
*基金项目：江苏省333高级人才培养工程(20090109)；南京中医药大学青年自然科学基金（11NZY04) 南京中医药大学第二临床医学院康复治疗教研室，南京，210023；2
南京医科大学附属江苏省人民医院康复医学科；3
通讯作者
作者简介：王尊，男，讲师；收稿日期：2013-03-19
www.rehabi.com.cn
291