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中国康复医学杂志，2007年，第22卷，第10期Chinese Jourmal of Rehabilitarion Medieine，Oet.2007，Vol.22,No.10
·基础研究·
运动血压反应与血流调控血管舒张功能的关系梁崎1王于领1刘东红2甘晗靖3孙冰2王礼春2麦炜颐2马
6虹2,4
目的：探讨中年人群肱动脉血流调控血管舒张功能与单次极量运动和恢复期血压反应之间的关系。方法：健
摘要
康中年志愿者76人，完成1次症状限制性运动平板试验及1次经体表高频超声检测脉动脉血流调控内皮依赖舒张功能（flowmediateddilation，FMD）和非内皮依赖血管舒张功能（nitroglycerinmediateddilation，NMD）的检测。按性别分为两组，分别将各个血压指标与FMD、NMD及各个可能的影响因素做Pearson相关，并通过多元逐步回归的方
法，检测出运动高峰期和恢复早期血压的影响因子。
测因子(P=0.008).与运动后恢复
1minSBP变化的39 著负相关(P=0.007
0.003)，
F
化的17.1%和12.5%。结论：血
结果；男性志愿者中,FMD与运动前收缩压(SBP)、脉压(PP)、2
目1分钟SBP相
的
内皮舒张
HS相单
P<0.001)及年龄(P=0.013),分别解释恢复期
SBP、PP、MAP 显
P的独立预测因子
P
夏期1minSBP变
有关，运动高峰期及恢复早期过高的SBP可能提示血
可运动血压度
支车
管内皮功能不全，运动及恢复期血压检测有助于发现内皮功能不全的个体。关键词
运动；血压：运动试验；血流调控血管舒张功能；内皮功能不全
中图分类号：R544，R493
文献标识码：A
文章编号：10011242(2007)-100888-05
The relationship between flowmediated dilation and blood pressure response to exercise/LIANG Qi, WANG Yuling, LIU Donghong, et al//Chinese Journal of Rehabilitation Medicine,2007,22(10) :888—892
Abstract
Objective: To examine the relationship between endothelial vasodilator
function and blood pressure
response to exercise in midaged people. Method: Healthy subjects, 36 men and 40 women with mean age 49.6±
L. Blood pressure was measured with automatie BP
4.1 years perfomed syndromelimited exercise test on treadmill.
instrument. Endothelial vasodilator function was assessed as brachial artery flowmediated dilation during reactive hyperemia in another day. Result: Among men, flowmediated dilation (FMD) correlate negatively with preexercise SBP, PP, 2stage SBP and MAP. After stepbystep multifactor
regression analysis, resting SBP was found to be
exerciseSBP
the only independent predictable factor of peak
0.001)of the variance
ce in SBP at
minut
afte
women, flowmediated dilation
(FMD)
significantly
MAP at 1 minute after
exercise
After
ste
only dependent predictable factor of peak
(P=0.008). Resting SBP also explained 39.1%(P< e explained additional 24.4%(P=0.013). Among
and
age
correlate negatively with peak exercise SBP, and SBP, PP
multifactor
exercise
SBP
regression analysis, resting SBP was found to be the
(P=0.003) and explained 17.1% of the variance in SBP at
1 minute after exercise (P=0.004) and FMD explained the additional 12.5% (P=0.013). Conclusion: We suggest that endothelial vasodilator function may contribute to blood pressure response to exereise. Exaggerated SBP at peak uoaunaeaoa de raroaan oa ea unp pueasaraa
Author's address Dept. of Rehabilitation Medicine, The First Affiliated Hospital of Sun Yat sen University.
Guangzhou, 510080 Key words
s exereise; blood pressure; exercise treadmill test; flowmediated dilation; endothelial dysfunction
既往的研究表明，运动及恢复期异常的血压增高与心血管疾病的发生危险性增加有关川,并且与炎症因子及颈动脉硬化密切相关(2-3,提示其与血管内皮功能不全关系密切，并且可能是内皮功能不全的标志围。但是目前关于血管内皮舒张功能和运动及恢复期血压变化之间的关系的研究并不多。本研究的目的即在于探讨运动及恢复期血压变化的影响因素，了解肽动脉血流调控血管舒张功能(flow-
mediateddilation，FMD）以及非内皮依赖血管舒张（nitroglycerin-mediateddilation，NMD）是否与运动
中山大学附属第一医院康复医学科，广州，510080
中山大学附属第一医院心血管内科深圳市人民医院超声科
通讯作者；马虹(广州中山大学附属第一医院心血管内科)
作者简介梁崎，女，博士，主治医师收稿日期：20070417