中国魔复区拿渠志2010年，第25卷，第8期
·临床研究·
新生儿缺氧缺血性脑病早期干预效果评估
王桂芝！陈燕惠23
摘要
曾仁和1
目的：探讨小儿神经发育学评估方法对新生儿缺氧缺血性脑病(HIE)早期神经行为异常评定的应用价值，并评价早期干预的疗效。
方法：中、重度HIE新生儿共71例，其中干预组44例，非干预组27例。采用家庭与门诊相结合的干预模式，根据神经发育学评估结果结合Vojta诱导疗法、Bobath法胶体功能训练法进行个别强化训练。两组儿童均接受常规育儿指导。采用Gesell婴幼儿发育检查量表评价神经发育情况。
结果：Gesell评分(DQ)，在24月龄时两组比较均无显著性差异（P>0.05)；在6、9月龄时干预组各能区DQ高于非干预组(P<0.01)，18月龄时干预组与正常组在各能区DQ比较无显著性差异(P>0.05)，均明显高于非干预组(P<0.01)。结论：中、重度HIE患儿有较高的不良预后发生率，早期个体化的综合干预可显著提高早期干预的疗效。
关键词
缺氧缺血性脑病：新生儿；神经行为；早期干预
中图分类号：R722
文献标识码：A
文章编号：1001-1242(2010)-08-0747-04
An assessment of the effects of early intervention on newborns with hypoxic ischemic encephalopathy/ WANG Guizhi, CHEN Yanhui, ZENG Renhe/Chinese Journal of Rehabilitation Medicine, 2010, 25 (8):
747750 Abstract
Objective: To study the value of neurodevelopment assessments in predicting the damages in neurological function
of newborms with hypoxic ischemic encephalopathy(HIE) and the effects of early intervention. Method: Objects of the study included 71
newboms with middleand serious HIE,among whom 44 newboms were
divided into the early intervention
pattem of the combination
training
were
administered
parental guidan
Result: betweer
age
of
the age
M
onth
18
months
(P>0.05);
in the early
DO
kroup,
famy
and
individuak ontf
witr
and27newborns
clinic
iccording
were in the non-intervention group. The intervention
applied. Vojta inducement training and Bobath limb function
the nbu
attribute
results of neurodevelopment. Regular routine
sused
in development quotient(DQ)
difference
between the two groups (P>0.05). At the
group was higher (P<0.01). At
intervention
statistical difference between two groups
that in nonintervention group(P<0.01).
obviously
higher than
Conclusion: There is a higher incidence
tt
o
newboms with middle and serious HIE.
The
poor prognosisin
effects of early intervention can greatly improved by using early individualized comprehensive intervention. Author's address
Pediatric Department, Affiliated Hospital of Putian College, Teaching Hospital of Fujian Medical
University,Putian,351100
Key words
hypoxic ischemic encephalopathy; newbom ; neurological behavior;early intervention
DO110.3969j.issn.10011242.2010.08.008
*基金项目：莆田市科技局资助课题(2007D08）
福建医科大学协和临床学院儿科；3
1福建省莆田学院附属医院（福建医科大学敦学医院)儿科，351100;2
通讯作者
作者简介；王桂芝，女，副主任医师，硕士；收稿日期：2009-09-03
wnte.rehabi.com.cn
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