试验研究
中国食品添加剂 China Food Additives
顺式一二氢茉莉酮酸甲酯的合成进展
贺建伟，郑福平，孙宝国
（北京工商大学化学与环境工程学院，北京100048）
摘要：二氢茉莉酮酸甲酯是合成香料有机化学品，其合成方法已经被研究了数十年，但是高品质的顺式-二氢茉莉酮酸甲酯的合成在国内还未实现工业化，因此有必要对其合成方法进行总结。本文概述了以环戊烯酮为起始原料选择性地合成顺式异构体、以环戊烯酬的取代物为起始原料来合成顺式异构体、以五元环类手性物质为起始原料合成顺式异构体和电化学的合成方法四种不同的合成顺式异构体的方法，并且通过对各方法的主要合成路线的原料获取的难易、反应条件是否容易实现、产率等影响因素进行了简单的讨论和评述，得出了各反应路线都有自己的优缺点，但反式-二氢莱莉酮酸甲酯只要通过对温度、pH值、溶剂等进行简单的条件摸索，转化为高品质的顺式二氢茉莉酮酸甲酯在理论上具有较大的可能性，比较适合我国的工业化。
关键调：香料；顺式二氢莱莉酮酸甲酯；合成；工业化
中图分类号：TS202.1
文献标识码：A
文章编号：10062513(2010)01008106
Synthesisprogressofcis-methyldihydrojasmonate
HE Jian-wei, ZHENG Fu-ping, SUN Bao-guo(School of Chemical and Environmental Engineering
Beijing Technology andBusiness University，Beijing100048，China）
Abstract: Methyl dihydrojasmonate is an important synthetic perfume product. Synthesis of methyl dihydrojasmonate has been studied for decades, but synthesis of cis-methyl dihydrojasmonate with high-quality have not yet been industri-alized. Therefore, it is worth summarizing its synthesis methods. This paper provides an overview of four types of syn thesis methods of cis-methyl dihydrojasmonate by selective synthesis of cis-isomer for eyclopentyl ketene, replaced cy-clopentyl ketene, pentagon-type chiral material for the starting material, and by electrochemical synthesis, This paper also briefly comments on each method in terms of difficulty in obtaining starting material, achieving reaction conditions, production rate and so on. It shows that although every reaction method has its own advantages and disadvantages, chan ging trans-methyl dihydrojasmonate into high-quality cis-methyl dihydrojasmonate has great potential as long as tempera ture, pH, solvent conditions are taken into account. Cis-methyl dihydrojasmonate is very suitable for Chinese indus tries.
Key words: perfume; cis-methyl dihydrojasmonate; synthesis; industrialization
二氢茉莉酮酸甲酯（图1）是人工合成的类茉莉酮类化合物，目前尚未发现它存在于天然香料中)，它的合成方法较为方便，价格较低廉，
收稿日期：200905-14
适合大量生产，所以它是现代香料工业中十分重要的一种香料。二氢莱莉酮酸甲酯为无色至淡黄色液体，具有浓郁的莱莉香气，又带有清新兰
作者简介：贺建伟（1983-），男（汉），山西人，硕士研究生，研究方向：香料香精的合成与制备。
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