现代肿瘤医学2011年6月第19卷第6期
臣论
著臣
◆基础研究分
MODERN ONCOLOGY,Jun.2011,VOL19,NO.6
· 1045 ·
胸腺瘤组织中的肿瘤相关巨噬细胞数与其分级、浸润以及患者预后密切相关
肖永春'，王璐"，张玮”，姚莉"，范林妮"，朱瑾，刘一雄"，黄高昇
Therelationbetweentumorassociatedmacrophagesandtheclassification,invasionand XIAO Yong - chun', WANG Lu',ZHANG Wei’, YAO Li?,FAN Lin ni',ZHU Jin',LIU Yi - xiong',HUANG Gao-sheng
'Department of Pathology, Xjing Hospital, The Fourth Military Medieal University, Xi'an 710032, China; "Department of Pathology Tangdu Hospital,The Fourth Military Medical University,Xian 710038,China.
[ Abstract] Objective: To discuss the relation between tumor associated macrophages( TAMs) and its clinicopatho-logical characteristics by counting TAMs in thymoma, and to provide a potential new indicator for the pathological di-agnosis and evaluation. Methods : Immunohistochemistry was used to detect TAMs in 95 examples of thymus lympho-ma tissues. The prognosis of patients was followed up. Statistical test was employed to analyze the relation of TAMs cells and the clinicopathological characteristics. In addition, the patients survival was analyzed by Kaplan - Meier method. Results: The percentage of TAMs cells varied in different substype B, , B, ,B, , C of thymoma, with 2. 9% , 5.4% , 11.9% and 13. 2 % respectively( P <0. 05 ), and the positive rate was gradually increased with the pro grassion of malignacy degree, The positive rate in invasion thymoma was significantly higher than that in other type of thymoma( P <0. 05 ). For survival analysis, the expression of TAMs, subtype as well as the invision were posotively corelated with the prognosis of thymoma patients. Conclusion: TAMs cells are closely related with pathological type
and invasion, and could provide an objective marker for prognosis of thymoma patients.[Key words]thymoma; invasion; prognosis; TAMs
Moderm Oncology 2011,19(06) :1045 1049
目的：检测胸腺瘤组织中肿瘤相关巨噬细胞（tumor一associatedmacrophages，TAMs）细胞数，探讨
【摘要】
TAMs与胸腺瘤临床病理特征的联系，为胸腺瘤的病理诊断及预后评估提供简易可行的新指标。方法：采用免疫组织化学法（SP法）检测95例胸腺瘤组织中的TAMs，电话随访及医院病历记录收集随访资料。单因素检验分析TAMs与胸腺瘤多种临床病理特征的联系，Kaplan-Meier生存曲线分析患者的生存状况。结果： TAMs在不同亚型胸腺瘤中的细胞数明显不同,在B;、B、B,、C型肿瘤组织中随肿瘤恶性度增加而阳性率逐渐增高，其百分率分别为2.9%、5.4%、11.9%、13.2%（P<0.05），在侵袭性胸腺瘤中的阳性率也明显高于非侵袭性胸腺瘤（P<0.05）；单因索分析表明TAMs表达、胸腺瘤分型、侵袭性与胸腺瘤患者术后远期生存率有显著相关性。结论：胸腺瘤组织中TAMs细胞数与其病理分型及侵装性密切相关，检测TAMs可为判断胸腺瘤惠者的预后提供简单易行的客观依据
【关键调】胸腺瘤；侵袭性；预后；肿瘤相关巨噬细胞
【中图分类号】R730.2;R736.3
【文献标识码】A
【文章编号]16724992(2011)06104505
【收稿日期】【修回日期】【基金项目】【作者单位】
【作者简介】【通讯作者】
2010 12 30 9011
国家自然科学基金资助项目（编号：30870947）
1第四军医大学西京医院病理科，陕西 1第四军医大学唐都医院病理科，陕西
西安西安
710032 710038
DOI;10. 3969/j. issn. 1672 4992. 2011. 06. 01
肖永春（1979-），男，吉林九台人，主治医师，硕士，主要从事肿瘤相关巨噬细胞与胸腺瘤的关系研究。E-mail；xiaoyoangchun@ 163.com
黄高异（1945-），男，河南傻师人，教授，博士生导师，主要从事肿瘤病理学的教学和研究工作。E-mail；huanggs@fmmu.edu