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赵永利,等血脑屏障通透性最大化时间窗指导非小细胞肺癌多发脑转移治疗的价值分析
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（编校：国沛）
血脑屏障通透性最大化时间窗指导非小细胞肺癌多发脑转移治疗的价值分析
赵永利，董记刚，李波，李茂江，崔岩,孙笑笑
The value analysis of blood brain barrier permeability in the treatment of multiple brain
metastases patients with non-small cell lung cancer Zhao Yongli,Dong Jigang,Li Bo,Li Maojiang,Cui Yan,Sun Xiaoxiao
Department of Radiation Oncology,Jiaozhou Central Hospital, Shandong Qingdao 266300, Chind.
[ Abstract] Objective : To investigate the value of blood brain barrier pemeability in the treatment of multiple brain metastases of non small cell lung cancer. Methods : Used a retrospective study,from the August 2012 to December 2015 ,90 multiple brain metastases patients with non small cell lung cancer in the diagnosis and treatment of our hospital were selected, and were equally divided into group A, B, C with 30 patients respectively accorded to the radia-tion therapy oncology group ( RTOG) independent recursive grading index. Group A was given the recombinant human vascular endothelial inhibin ( Endostar) treatment before the chemoradiotherapy about 1 week , and intravenous chem-otherapy was started when the whole brain radiotherapy was 30 Gy. Group B was given Endostar and chemoradiothera-py at the same time,and synchronous intravenous chemotherapy, when whole brain radiotherapy was to 30 Gy. Group C was given the chemoradiotherapy when the Endostar was started , and chemotherapy was did when whole brain ra-diotherapy was started. Prognosis of three groups were evaluated. Results : The efficiency in the group A, B, C were 66. 7% ,46. 7% and 26. 7% with significant difference ( P <0. 05). The most common side effects of the three groups include white blood cell decline, diarrhea, nausea, vomiting, liver function damage, and the incidence rates in the group A,B,C were 66. 7% ,66. 7% and 63. 3% respectively, with no significant difference ( P > 0. 05). The KPS score after treatment in the group A,B, C were (67. 24 ± 7. 39) points, (56. 30 ±5. 20) points and (48. 20 ± 8. 14) points. The progression free survival time in the group A, B, C were (11. 35 ±4. 20) months, (9. 23 ±4. 11) months and (7. 40 ± 3. 22) months and survival time were (18. 34 ±5. 13) months, (16. 02 ± 3. 89) months and (13.98 ± 4. 11) months with significant difference ( P <0. 05). Conclusion: Endostar used after 1 week can produce a specific time window in the multiple brain metastases patients with non small cell lung cancer, and then the whole brain ra-diotherapy to 30 Gy can reach maximum of permeability of blood brain barrier, which can improve brain chemotherapy drug blood concentration, so as to improve the curative effect, improve the prognosis of patients with prolonging the survival time,and it will not increase the occurrence of adverse reactions.
[ Key words]blood brain barrier, time window, non small cell lung cancer patients with multiple brain metastases, Endostar, toxicity
Modem Oncology 2017,25(14) :2238 2242
【摘要】
目的：探讨血脑屏障通透性最大化时间窗指导非小细胞肺癌多发脑转移治疗的价值。方法：采用回
【收稿日期】
2017 01 16
【基金项目】【作者单位】【作者简介】
青岛市2015年度医药科研指导计划项目（编号：2015－WJZD070）青岛市胶州中心医院放疗科，山东青岛266300
赵永利（1965-），男，山东高密人，硕士，主任医师，主要从事各种肿瘤的放疗、化疗、生物靶向治疗等方面的研究。