北2009年8月第17卷第8期
现代肿瘤医学
Res,2001,483(1 2) :19 26.
[27][28][29]
[30][31]
[32]
Goggins M,Shekher M,Tumacioglu K,et al. Genetie alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocareinomas [J]. Cancer Res, 1998, 58 ( 23 ) : 53295332.
Chen T, Yan W, Wells RG, et al. Novel inactivating mutations of pu pea u auag odaar [ odk oaey qimo Suuuosurn neck cancer metastases[J]. Int J Cancer,2001 ,93 (5) : 653 661.
Kang SH,Bang YJ,Im YH,et al. Transcriptional repression of the VN iq aua odar 1 adi; aq oary sod uirogsun] methylation results in the development of TCF β resistance in human gastrie cancer [J]. Oncogene, 1999, 18 ( 51 ) : 7280 7286.
Miyaki M, lijima T, Konishi M,et al. Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis[J]. Oncogene,1999,18(20) ;3098 3103.
Natsugoe S,Xiangming C,Matsumoto M,et al. Smad4 and trans-foming growth factor β1 expression in patients with squamous cell carcinoma of the esophagus[ J]. Clin Cancer Res, 2002, 8 (6) : 18381842.
Xu J, Attisano L. Mutations in the tumor suppressors of Smad2 and Smad4 inactivate transforming growth factor beta signaling by tar-
[][34][35]
[9E][37]
[38]
·1571 ·
geting Smads to the ubiquitin proteasome pathway[ J]. Proe Natl Acad Seci USA,2000,97(9) :4820 4825.
Kim YH, Lee HS, Lee HJ,et al. Prognitic significance of the ex-pression of smad4 and smad7 in human gastrie carcinoma [ J]. Annal Oncology,2004,15(4) ;574 580.
Boulay JL,Mild G,Lowy A,et al. Smad7 is a prognostie marker in petients with colorectal cancer[J]. Int J Cancer,2003, 104(4) : 446449.
Siegel PM,Shu W, Cardiff RD,et al. Transfoming growth factor β signaliag impairs neu induced mammary tumorigenesis while promoting pulmonary metastases [J], Proc Natl Acad Sci USA, 2003,100(14) :8430 8435.
Tang B, Vu M, Booker T,et al. TCF β switches from tumor sup pressor to prometastatic factor in a model of breast cancer progres-sion[ JJ. J Clin Invest,2003,112(7) ;1116 1124.
es oane e asd a e e 3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines[ J]. CancerRes , 2003 , 63 (23 ) ; 8284 8292.
Zagzag D,Salnikow K, Chiriboga L,et al. Downregulation of msjor bistocompatibility complex antigens in invading glioma cells: stealth invasion of the brain[J]. Lab Invest,2005 ,85(3) :328
341.
医学图像融合技术在肿瘤放射治疗中的应用
鹿
红，李
兵，朱锡旭
Applicationof medicalimagefusion inradiation therapyforcancer LU Hong,LI Bing,ZHU Xi - xu
(编校：任永或）
Department of Radiation Oncology,Nanjing General Hospital of Nanjing Military Command,PLA, Nanjing 210002, China.
[ Abstract] The technique of medical image fusion is being investigated in radiation therapy , especially in modem ac-curate radiotherapy. The classification, method and procedure of image fusion were introduced and different imaging modality applications in radiotherapy were reviewed. It is obvious that medical image fusion will play an important role in biologically conformal radiotherapy.
[Key words] medical imaging; image fusion; radiation therapy
Modem Oncology 2009,17(08) :1571 1574
【指示性摘要】医学图像融合技术一个非常重要的应用领域就是肿瘤的放射治疗，特别是对于精确放射治疗。本文简介医学图像融合技术的分类及主要方法和实施步骤，并综述各种图像融合技术在不同肿瘤放疗中的
应用，对其在生物适形放射治疗中的应用前景作一展望。【关键词】医学图像；图像融合技术；肿瘤放射治疗
【中图分类号】R730.55
【收稿日期】【修回日期】【作者单位】【作者简介】【通讯作者】
2008~0822 2008 11 11
【文献标识码】A
南京军区南京总医院放疗科，江苏
南京
210002
【文章编号]16724992(2009)08157104
鹿红（1974－），女，甘肃华亭人，主治医师，主要从事肿瘤放疗工作。
朱竭旭（1963-），男，江苏准安人，酬主任医师，硕士生导师，主要从事肿瘤放疗工作。