第18卷第1期 2018年2月
综述
过程工程学报
The Chinese Journal of Process Engineering
Vol.18 No.1 Feb.2018
D0l:10.12034/j.issn.1009-606X.217166
生物基有机酸提取分离技术研究进展鄂凌，傅宏鑫，王旭东，孙亚琴，戴建英，修志龙
(大连理工大学生命科学与技术学院，辽宁大连116024)
摘要：有机酸如乳酸、琥珀酸、柠檬酸、衣康酸、草果酸等在工业上有重要应用，随着食品、医药、化学合成等工业的发展有机酸需求骤增，发酵生产有机酸逐渐成为生物工程领域中一个重要而成熟的分支，但存在产物浓度低、成分复杂、后处理量大等问题。有机酸亲水性好、不同有机酸物理化学性质相近等特点导致产物分离提纯困难，成为制约生物法生产有机酸的瓶颈分离发酵液中有机酸的方法主要有沉淀法、萃取法、吸附法、离子交换法、膜分离法、电渗析法和酯化法等，通过各种分离方法的对比，发现单一的分离方法很难有效分离有机酸集成不同分离方法，可简化分离工艺，分离效果更好。此外，采用新型分
离耦合技术，可实现有机酸的连续或半连续生产，是未来发醇行业的一个重要发展方向。关键词：有机酸；分离；提取；萃取；离子交换；吸附：电渗析
中图分类号：TQ921
文献标识码：A
文章编号：1009-606X(2018)01-0001-10
RecentAdvancesonRecoveryandSeparationofBiomass-basedOrganicAcids
Ling YAN, Hongxin FU, Xudong WANG, Yaqin SUN, Jianying DAI, Zhilong XIU
(School of Life Science and Biotechnology, Dalian University of Technology, Dalian, Liaoning I16024, China)
Abstract: Organic acids such as lactic acid, succinic acid, citric acid, itaconic acid, and malic acid have important application in industry The demand for organic acids increased dramatically with the development of food, medicine and chemical synthesis. The fermentative eoeeoa fermentation-based routesforthe industrial production of organic acids have some problems such as low product concentration,complex composition of fermentation broth and downstream processing. Because of its good hydrophilicity, similar physical and chemical properties, separating and purifying organic acids from fermentation broths is difficult, The separation of organic acids becomes the main bottleneck for organic acid production by biological processes. A number of processes for organic acids recovery from fermentation broths have been studied in the literatures, including precipitation, extraction, adsorption, ion exchange, membrane separation, eeseeaeeeaaesee difficult to separate organic acids effectively.The integration of different separation methods can simplify the separation process and obtain excellent separation effect.In addition, continuous or semi-continuous production of organic acid is an important direction of future fermentation industry by the novel methods of separation coupling fermentation.
Key words: organic acids; separation; recovery; extraction; ion exchange; adsorption; electrodialysis
1前言
在能源需求不断扩大、石油资源日渐枯竭的情况下，以可再生生物质为原料的生物炼制技术越来越受重视，尤其是利用工业生物技术生产生物质能源和生物基大宗化学品.有机酸是重要的一类生物发酵产品，用途较广，代表性的有机酸发酵产品有乙酸、丙酸、丙酮酸、
收稿日期：2017-03-07，修回日期：2017-0526
基金项目：国家自然科学基金资助项目(编号：21476042)
内烯酸、乳酸、丁酸、琥珀酸、苹果酸、富马酸、戊二酸、衣康酸、柠檬酸、葬草酸、3-羟基丙酸、-氨基丁酸、10~18碳二元酸(长链二元酸)等
多数生物产品的生产过程是由菌体选育-菌体培养
（发酵）预处理-浓缩一产物捕集-纯化-精制等单元组成一般将菌体培养之前称为上游过程，后续过程称为下游过程或生化分离和纯化过程"，与上游过程相比，下游
作者篇介：率凌(1990-)，男，湖南省常德市人，博士研究生，生物化工专业；修志龙，通讯联系人，E-mail:zhlxiu@dlut.educn 引用格式：率凌，宏鑫，王旭东，等，生物基有机酸提取分高技术研究进展，过程工程学报，2018,18(1):1-10.
Yan L, Fu H X, Wang X D, et al Recent Advances on Recovery and Separation of Biomass-based Organic Acids (in Chinese) Chin. J. Process Eng, 2018, 18(1): 110, DOI: 10.12034/j.issn.1009-606X.217166.
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