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◆消化·泌尿系肿瘤心
维普资iRhtp-/www.cqip.com
MODERN ONCOLOGY,Feb.2008,VOL16,NO.2
原发孤立性肝癌经导管化疗栓塞后血清VEGF表达与碘油沉积的相关性
威跃勇，邹利光，刘卫金，郝萍，张青
The relationshipbetweentheserum VEGF and lipiodol retentionafftertranscatheterarterial
embolizationofthesolitarytypehepatocellnlarcarcinoma QI Yueyong,ZOU Liguang,LIU Weijin, HAO Ping,ZHANG Qing
Department of Radiology,Xinqiao Hospital,Third Military Medical Unitersity, Chongqing 400037, China.
[Abstract)Objective: To study the relationship between the serum vascular endothelial growth factor ( VECF) and lipiodol retention after transcatheter arterial embolization( TACE) of the solitary type hepatocellular carcinoma( HCC). Methods : Senum VECF expression level, was measured by quatitative sandwich enzyme linked immunosorbentassay(ELISA,R&D system) , before TACE 1 day and 1 day,1 week, 2 weeks, 1 month, 2 months after TACE in 36 pa-tients with HCC,and the percentage of lipiodol retention to the total tumor volume were measured at the same time. Results: The serum VEGF level reached a peak at 1 day after TACE, then decreased after 1 week, increased again after 2 weeks, then gradually rised to 2 months after TACE. Serum VECF expression increase was associated with the development of recurrence in hepatocellular carcinoma after TACE. The prognosis of the patients with rising VEGF concetrations was dismal. A significant correlation existed between the senum VEGF level and the percentage of lipi odol retention of 1 day ,1 month and 2 months after TACE. Conclusion: It is useful to test the serum VEGF level and the percentage of lipiodol retention, and may be as a novel prognostic predictor of the HCC treated by TACE treat-ment.
[ Key words]hepatocellular carcinoma;vascular endothelial growth factor; embolizaton
Moderm Oncology 2008 ,16(02) :0224 0226
目的：探讨原发孤立性肝细胞肝癌(HCC)经导管化疗栓塞(TACE)治疗前后血清血管内皮细胞生长
【摘要】
因子（VEGF）表达与碘油沉积的相关性。方法：采用酶联免疫夹心法（ELISA）对38例HCC患者分别于第一次TACE术前1天、术后1周、术后2周、术后1月及术后2月测量其血清VEGF表达水平，同期测量瘤体内碘油沉积的体积百分比，然后进行两者的相关性分析。结果：术后1天血清VEGF呈一过性增高，术后1周 VEGF的表达降至低谷，于术后2周开始缓慢上升，术后2月血清VECF值较术后1月明显升高。血清VEGF 的高表达与TACE后局部复发密切相关，血清VEGF值越高，其TACE疗效越差。血清VEGF值与碘油沉积率在术后1天、术后1月和术后2月有显著相关性。结论：血清VEGF与碘油沉积率在评价TACE疗效中有较
好的相关性，联合测量血清VEGF表达与碘油沉积率可较好地评价TACE的疗效。【关键词】肝细胞肝癌；血管内皮生长因子；栓塞
【中图分类号】R735.7
【文献标识码】A
原发性肝细胞肝缩（hepatocellularcarcinoma，HCC）经导管肝动脉化疗栓塞术（transarterial chemoembolization，TA CE)对不可切除HCC是最有价值的姑息性治疗方法，但它具有较高的复发率，而大量研究已表明其复发的原因与肿瘤的血管生成密切相关(")。CT扫描显示碘油的沉积与分布情况是目前TACE术后疗效评价最直观面常用的方法。本研究拟通过TACE术后定期测量血清血管内皮生长因子(vascular
【收稿日期】【修回日期】【基金项目】【作者单位】【作者简介】
2007 01 30 2007 0508
GE公司联合研发基金资助（编号：2004E039）第三军医大学新桥医院放射科，重庆400037
威跃勇（1969-），男，重庆人，副主任医师，副教授，硕士，主要从事肝癌的影像诊斯与介入治疗研究。
【文章编号】16724992(2008)02022403
endothelialgrowthfactor，VEGF）的变化，并与碘油沉积率多层螺旋CT(multi-sliceCT，MSCT）值进行相关性研究，以评价血清VECGF与碘油沉积率测量在TACE疗效中的价值。资料与方法
1.1
临床资料
病例入选条件：①经医学影像学发现直径为4cm-6cm 大小的摄立原发性HCC，且无门静脉主干或I、Ⅱ级分支门静脉癌栓（portal veintumorthrombus，PVTT）及明确肿瘤减化坏死者；②患者愿意接受TACE治疗者；③患者同意免费进行血清VEGF及CT随访检查者。病例排除标准：①经B超或CT引导下经皮穿刺活检排除患者为HCC者；②经TACE 治疗失败者；③TACE治疗前DSA造影明确门静脉主干或 1、Ⅱ级分支具有PVTT者;④TACE治疗后发现报立性HCC