·2750·
(GP Chinese General Practice Mg2013N16No8B
·短篇论著
新生儿B族链球菌败血症合并化脓性脑膜炎五例临床分析陈丽，吴本清，程涵蓉，唐沂，吴俊，燕旭东，涂惠英
【摘要】
探讨新生儿B族链球荫（CBS）败血症合并化脓性脑膜炎的临床特点。方法目的
回顾性分析
2010一2012年深划市人民医院新生儿病房住院的5例GBS败血症合并化脉性脑膜炎患儿的一般资料、临床特征、实验
室检查结果、影像学检查结果、治疗及转归。结果
5例GBS败血症合并化脉性脑膜炎患儿，均顺产、足月、无异常
出生史。1例早发型病例以黄症为首发症状，4例晚发型病例均发热伴不同程度的神经系统异常症状。2例患儿白细胞计数减低、1例升高，C反应蛋白水平均明垦增高，均对青寒素及万古寒素敏感。5例患儿给予综合治疗后存活，脑干诱发电位均通过。2例惠儿颅脑磁共振成像
（MRI）提示：脑软化灶，1例患儿有少许出血灶，余2例正常。随访1
年，1例有生长发育滞后，余4例生长发育正常。结论
新生儿GBS败血症合并化脓性脑膜炎的临床特点各异，须引
起重视。对于可疑惠儿应早期进行血培养确定病原菌，行脑势液检查，尽早用敏感抗生素治疗，减少后遗症的发生。
【关键词】
娶儿，新生；链球菌，无乳；脑膜炎，细葡性
【中图分类号】R722.131
【文献标识码】Bdoi：10.3969/j.issn.10079572.2013.08.064
陈丽，吴本清，程涵落，等，新生儿B族链球首败血症合并化性脑膜炎五例临床分析【J】，中国全科医学， 2013, 16 (8): 27502752.[www.chinagp.net)
Group B Streptococcal Septicemia Combined with Purulent Meningitis: Clinical Analysis of Five Cases
sCHENLi,WU
Ben qing, CHENG Han rong, et al. The Second Clinical Medical College of Ji'nan University, Shenzhen 518020, China
[Abstract]
ObjectiveTo explore clinical characteristics of neonates with group B streptococcal (GBS) septicemia
and purulent meningitis ( PM). Methods The general data, clinical features, laboratory and imaging findings, treatment and prognosis of neonates with GBS septicemis admited to this hospital from 2010 to 2012 were analyzed retrospectively.Results Five infants were diagnosed as CBS septicemia and purulent meningitis and all were vaginal delivery, full term without abnormal birth history. One early onset case had jaundice as the first symptom, 4 late onset case had fever complicated by different de-grees of neurological abnormalities. Leukocyte count decreased in 1 infant, increased in 1. C reactive protein increased re-markably, which was sensitive to penicillin and vancomycin. Five patients were given combined treatment and survived, brain-stem evoked potentials were passed. Brain magnetic resonance imaging ( MRI) demonstrated encephalodialysis in 2 patients, a few bleeding nidi in 1, the other 2 were normal. After 1 year of follow up, 1 had growth retardation, the other 4 were normal.
Neonatal GBS septicemia with purulent meningitis, which clinical features are different.The suspected neonates
Conclusion
should have blood cultures to confirm pathogen and cerebrospinal fluid examination as soon as possible, to undergo sensitive anti-biotics to reduce incidence of complications.
[Key words]
Infant, newborn; Streptococcus agalactiae; Meningitis,bacterial
作者单位：518020广东省深圳市，暨南大学第二临床医学院，深圳市人民医院新生儿科
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（收稿日期：2013-04-10；修回日期：2013-07-25）
（本文编辑：鹿飞飞）