2017-06
生物制药与研究
当代化工研究
henml
161
单磷酸阿糖腺苷与利巴韦林治疗手足口病疗效对
比的系统评价和Meta分析
★李其亮1
谢安安？
李其星3
（1.钦州学院医务所广西535000 2.融水县人民医院药剂科广西545300
3.钦州市第一人民医院钦州港分院药剂科广西535000）
系统评估中国单磷酸阿糖腺菩对比利巴书林在手足口病的疗效，为临床治疗提供循证参考。方法计算机检索中国知、维普数
摘要：目的
据库、万方数据库，搜集自建库至2016年12月单磷酸阿糖腺等（实验组）对比利巴书林（对照组）治疗手足口病的随机对照试验（RCT），使用RewMan5.3版本统计款件遵行Meta分析。结果经筛造最终纳入14高文账，包括2293例手足口病悬者。Meta分析结果星示，实整组惠者在总有效率、意消除时间、退热时间、口腔灵愈合时间方面比较均优于对照组，差异均具有统计学意义(P<0.05），总有效率[0R5.17，95%CI(3.80,7.03)，免参消除时间[MD=1.00，95%CI(1,55，0.45)],逐热时间[MD=0.73，95%CI(1,16，0.30)]
，口腔炎愈合时间
[MD=1.50，95%（2.30，=0.70）】。结论单磷酸阿格像苷治疗手是口病的疗效限利巴书林对比，前者治疗有效率更高，起效更快，关键调：单磷酸阿糖醇苷；利巴书林；手足口病；系统评价；Meta分析
中图分美号：R
文献标识码：A
TherapeuticEfficacyofAdenineArabinosideMonophosphateandRibavirinforHandFoot
Mouth Disease:a systematic review and Meta-analysis
Li Qiliang', Xie An'an’, Li Qixing?
(1.Qinzhou University Infirmary, Guangxi, 535000
2.Department of Pharmacy,The People's Hospital of Rongshui, Guangxi, 545300 3.Department of Pharmacy,The First People's Hospital of Qinzhou, Guangxi, 535000)
Abstract : Ohjective To evzluate thenqpeic eficacy of adenine anabinoside moniophiosphate and ribvirin Jor hand foot mouth disease, and ro provide evidence-based rgference for clinical areafment. Methods Rerieved jfrom Chinese jotrmal _fidl-fexz databasefonkij), Chinese scientific journals database, Wanfang data-base, nandomized confrolled trials(RCT)abou adenine arabinoside monophosphate(itrial group)and ribrvirin(conirol group) in the freabmenf of cerebral edema for handfoot mouath disease were collected,from the date oftheir establishmenr to December, 2016., Afier evaluating the quality of inchaded sfudlies and exfracrting data,Metd-analysis was performed by asing Rev:Man 5.3 statistical sofiware. Resualts -4fier screening d fotal of 14 RCZB were inchded, involving 2293 partients. Meta-analysis showed rhaf: the lotal efective rate, herpes elimination fime, antipyeric zime and healing time of Stomatitis of trial group were signijficantly better than those of confrol grotp. There wzs statistical signijficance.(P<0.05),compared with control grotp; the fota/ efective nzfe/OR=5.J7, 95% CI(3.80, 7.03),herpes elimination time/MD=-J.00, 95% CI(I.55, -0.45)/, dantipsreric time/MD=-0.73, 95% CI( 1.16, -0.30)] , hearling rtime of stomaritis [MD=-J.50, 95% , CI(-2.30, -0.70)]. Conchesion Therapeartic eficacy of adenine arabinoside monophosphate is befter:
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【作者简介】
周翊（1987~），男，云南省等洱市环境监测站；研究方向：环境监测技术，环境化学分析，生物化学。
(资任编辑：刘林林)