第19卷第3期 2011年3月
文章编号
1004924X(2011)03-0651-06
光学精密工程
Optics and Precision Engineering
Vol.19No.3
Mar.2011
基于微流体技术的组织液透皮抽取装置
于海霞，栗大超，刘同坤，徐可欣
（天津大学精密仪器与光电子工程学院精密测试技术及仪器国家重点实验室，天津300072）
摘要：为了在连续血糖监测中实现微量组织液的透皮抽取和收集，采用微流体技术，利用象二甲基硅氧烷（Polydimethyl-siloxane，PDMS)设计加工了组织液透皮抽取装置首先，采用模塑法加工得到组成装置的4层PDMS。接着，采用氧等离子体键合方法键合PDMS获得能够产生真空负压的文氏管，用于注人生理盐水、抽取组织液和收集组织液的腔体，控制流体传输的气动阀以及连接各部分的微管路4部分装置。然后，测量文氏管的输出负压和气动阅的关闭压强。最后，检验了装置抽取和收集组织液的功能实现情况。结果显示，将220kPa(绝对压强》的氮气通人文氏管的输人端口，在文氏管的喉部端口获得了92kPa(绝对压强）的真空负压。
另外，只需低于65kPa（相对压强)的压强就可以关闭采用
PDMS薄膜加工的常开型气动阅。该装置可在气动阅的控制下，利用文氏管产生的真空负压，自动完成生理盐水的注人、组织液的抽取和收集。
关
词：微流体技术；PDMS文氏管；组织液；连续血糖监测键
doi:10.3788/OPE.20111903.0651
中图分类号：TH789;TH47
文献标识码：A
Interstitialfluidtransdermalextraction tool based on microfluidics technology
YU Hai-xia,LI Da-chao,LIU Tong-kun,XU Ke-xin
(State Key Laboratory of Precision Measuring Technology and Instrument,College of Precision InstrumentandOpto-electronics Engineering,TianjinUniversity,Tianjin 300072,China)
Abstract: A microfluidic based Interstitial Fluid (ISF) transdermal extraction tool made from polydim ethylsiloxane (PDMS) was designed to the application of continuous glucose monitoring. Four layers of PDMS fabricated by replica molding process were bonded together using oxygen plasma to construct the device, including a Venturi tube for vacuum generation, chambers for the introduction of ISF and normal saline solution, pneumatic valves for fluid control, and interconnected microchannels. Then, the output vacuum of Venturi tube and the close pressure of pneumatic valve were measured. Finally, the ISF extraction and collection function was tested. Results show that the vacuum pressure is used for fluid manipulation and a 92 kPa (absolute pressure) vacuum is achieved, when 22o kPa (absolute pressure) external pressure is applied to the Venturi tube. Moreover, the normally open pneumatic valves can be closed under the operating pressure,less than 65 kPa (relative pressure). Under the con-trol of pneumatic valves, the normal saline injection, ISF extraction and collection function of the tool
收稿日期：2010-04-19；修订日期：2010-07-24
基金项目：国家自然科学基金青年教师基金资助项目（No.30800239)：天津市自然科学基金资助项目（No.
07JCYBJC04900）；教育部博士学科点青年教师基金资助项目（No.20070056075）