第32卷第1期 2017年1月
Article ID: 1000-324X(2017)01-0107-06
无机材料学报 Joumal of Inorganic Materials
Vol. 32 No. 1 Jan.,2017
DOI:10.15541/jim20160143
Sol-Gel-derivedMesoporousCalciumAluminumPhosphateBioactive
GlasseswithHighSurfaceArea MA Peng-Feil.2, LI Ri-Hong', ZHANG Long
(1. Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sci-ence, Shanghai 201800, China; 2. University of Chinese Academy of Sciences, Beijing 100039, China)
Abstract: High surface area mesoporous bioactive glasses (MBGs) with composition CaO-Al,O,-P,O, were fabricated using a simple aqueous Sol-Gel method without any template. Structural characterization of the phosphate-based MBGs was performed by BET, DTA, XRD and FTIR, and MBGs' in vitro bioactivity was evaluated by soaking them in simulate body fluid for up to 15 d at 36.5°C. The highest specific surface area is found to be 461.1 m°/g for the MBG with 5mol% CaO, and it decreased with increasing CaO content. And the glass structure for all the samples was confirmed by XRD and FTIR. However, the MBG with 20mol% CaO exhibits the best in vitro bioactivity using simu-lated body fluid among all samples. The unique combination of a higher specific surface area and relatively high CaO content enables mesoporous calcium aluminum phosphate bioactive glasses to be promising candidates for biomedical applications.
Key words: mesoporous; phosphate glass; bioactive; Sol-Gel
Bioactive glasses are materials which are supposed to achieve the biomedical aim of scaffold preparation/l-1, dental restorations/+-5], drug loading/6-7, coating of metal and polymer implants$89,etc.Optimal bioactivity, bo compatibility and degradation property are key features for bioactive glasslio, The method of increasing the specific surface area to improve these features of bioactive glass by Sol-Gel is efficient and remains a favoritc among the scientific community(12-13]
Bioactive glasses with a desired pore size, porosity and the pore interconnectivity are needed to serve as a physical support to guide the formation of the new bone tissue. Indeed, the adhesive substrate for implanted cells is supplied via the structure of the porous space across the materialsl14-16], The nanoscale pores in the bioactive glass play an important role in promoting cell adhesion, and the adsorption of the biological metabolites and release of usefual elements in materials is accelerated due to the po-rosityl17-18], Among the porous materials,mesoporous ma terials with poresizebetween2 nm and 5o nm attracts more attentions for using as bioactive glass to repair the defective bone, owing to their high specific surface area, high pore volume and superior bioactivel1-21]
So far, the major reported Sol-Gel-derived mesoporous bioactive glasses have been prepared by surfactant or tem-plate depend on the peculiar chelation of metal precursors in aqueous solution for the first, which leads to partial crystallization after the calcination of the gelatin at high temperature22] Thus upon degradation of the implant, small crystalline particles still exist which can cause ster-ile inflammation, which has been reported clinically24-25]
Phosphate-based bioactive glasses have emerged as promising bone substitute materials for bone tissue engi-neering applications because their chemical composition is very close to that of natural bone, and the rate of dissolu-tion in end application can be more easily modified26-2m Moreover, the addition of an appropriate amount of alu-mina to phosphate-based bioactive glasses can control their dissolution rate and increase mechanical properties and bioactivity[28-30]
The aim here was to develop a phosphatc bioactive glass with mesoporous structure in Sol-Gel route. In the present work, mesoporous calcium aluminum phosphate bioactive glasses were synthesized through the Sol-Gel method, free of the annexing agent.
Reeeived date: 2016-03-14; Modified date: 2016-06-03
Foundation item: National Natural Science Foundation of China (1308491G00)
Biography: MA Peng-Fei (1989), male, candidate of Master degree. E-mail: mapf@shanghaitech.edu.cn Correspoading author: ZHANG Long, professor. E-mail: Izhang@siom.ac.cn
LI Ri-Hong, associate professor. E-mail: lirihong@siom.ac.cn
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