
现代肿瘤医学2015年5月第23卷第10期
MODERN ONCOLOGY,May.2015,VOL.23,NO.10
早期营颈腺癌术后的预后分析韩志红",张秀珍",田小飞",杨雪梅",韩星梅”
·1435
Prognostic analysis of early-stage cervical adenocarcinomatreated with radical hyster-ectomy and systematic lymphadenectomy
Han Zhihong',Zhang Xiuzhen',Tian Xiaofei',Yang Xuemei',Han Xingmei?
'Department of Gynecology Oncology,Shaanxi Prouincial Tumor Hospital,Shaanxi Xian 710061,China;Department of Gynecology and Obstetrics,the Second Hospital of Changzhi,Shanxi Changzhi 046000, China.
[Abstract] Objective: To investigate the prognostic factors and treatment outcome in early adenocarcinoma patients of the uterine cervix underwent radical hysterectomy with systematie lymphadenectomy. Methods: From 2005 to 2009, 96 cervical adenocarcinoma treated with hysterectomy and systematie lymphadenectomy were retrospectively analyzed, the relationship between 5 year survival rate and clinical pathological parameters, Cox regression was used to deter-mine independent prognostic factors. Results : The 5 year overall survival rate was correlated with tumor gross,clinic stage,lymph node metastasis,lympho vascular space invasion and chemotherapy times (P <0. 05). Univariate anal-ysis revealed prognostic factors of patients with cervical cancer were tumor gross, clinic stage,lymph node metastasis and chemotherapy times. Multivariate analysis showed that lymph node metastasis and chemotherapy times were the prognostic factors of patients with cervical cancer(P<0. 05). Conclusion:Lymph node metastasis and chemotherapy times were independent prognostic factors for cervical adenocarcinoma. Regular,sufficient and timely assistant chemo
therapy are the necessary measures to improve prognosis and the life quality of early cervical adenocarcinoma.[Key words]early cervical adenocarcinoma;chemotherapy;prognosis
Moderm Oncology 2015,23(10) :1435 1437
【摘要】目的:研究早期(I,-Ⅱ。期经根治性子宫切除+盆腔淋巴结清扫术后宫颈腺癌患者的预后因素及治疗结果。方法:收集2005年至2009年经手术治疗的早期(I,-Ⅱ.期)宫颈腺癌96例患者的临床病理特征,分析与患者5年生存率有关的临床病理因素,Cox回归分析影响患者预后的因索。结果:肿瘤类型、临床分期、淋巴结转移、脉管瘤栓及其治疗方法与宫颈瘤的5年生存率有关(P<0.050)。单因索分析结果显示肿瘤类型、临床分期、淋巴结有无转移、脉管有无瘤栓与预后有关。多因素分析显示对宫颈腺癌患者生存有影响的因素是淋巴结有无转移和患者术后化疗次数。结论:淋巴结转移和患者术后的化疗次数是影响早期
宫颈腺癌术后患者独立的危险因素,术后正规、及时足量的辅助化疗可以改善患者预后和生存质量。【关键词]早期宫颈腺癌;化疗;预后
【中图分类号】R737.33
【文献标识码】A
【文章编号】16724992(201510143503
宫颈瘤是妇科最常见的恶性肿瘤之一,每年世界范围内约有50多万的新增病例[1]。近几年来宫颈癌的总体发病率及死亡率有所下降,但宫颈腺瘤发病率呈上升趋势,尤其是在年轻妇女中,比例占宫颈癌的20%[2],尤其宫颈腺癌预后差,难治愈,生存期短,需要我们引起重视。关于宫颈腺癌统一的治疗方案仍未确定,因此如何改善其预后就成为妇科恶性肿瘤治疗的一个重要课题,本研究旨在分析宫颈腺癌的临
【收稿日期】【修回日期】【作者单位】
【作者简介】
2014 09 15 2014 10 08
"陕西省肿瘤医院妇瘤科,陕西西安710061
2长治市第二人民医院妇产科,山西长治046000 韩志红(1982-),女,山西人,主治医师,主要从事妇科肿瘤的诊治工作。Email;hanzhihong415@163. com
DOI:10. 3969/j. issn. 1672 4992. 2015. 10. 33
床病理特征,探讨影响早期宫颈腺癌的预后因素,为临床上改善宫颈腺癌预后提供一种有效的策略。
1资料与方法 1.1研究对象
收集2005年5月至2009年5月在陕西省肿瘤医院妇瘤 0 期为I,-Ⅱ。期,行根治性手术治疗:术前未经放、化疗;病
理确诊为宫颈腺癌。 1.2方法
研究组51例,行宫颈癌根治术,有高危因素的患者术后行同步放化学治疗,所有患者行4-6周期TP方案(紫杉醇 +顺铂)化疗。对照组45例,行宫颈癌根治术,对于有高危因索的患者术后仅行同步放化学治疗,未行进一步治疗或行小于4周期的TP方案化疗。患者的年龄、宫颈肿瘤类型、局