第24卷第4期 2009年7月
文章编号：1000-324X(2009)04-0707-05
无机材料学报
Joumal of Inorganic Materials
Vol.24,No.4 Jul.，2009
DOI:10.3724/SP.J.1077.2009.00707
无定形磷酸钙的硬脂酸表面改性及其改性后的稳定性研究
李延报"2，李怀栋"，程新'，刘文浩'，李东旭，许仲梓
（1.南京工业大学材料科学与工程学院，材料化学工程国家重点实验室，南京210009；2.东南大学生物科学与医学工程学院，江苏省生物材料与器件重点实验室，南京210096）
摘要：将硬脂酸溶于热乙醇并以乙醇为反应介质在回流的条件下对无定形磷酸钙（ACP)粉末进行表面改性，利用活化率、接触角、红外谱图和热分析等研究了ACP的表面改性效果，结果表明ACP粉末表面有约4wt%的硬脂酸存在，硬脂酸可以与ACP以一COOCa和HPO的形式发生化学作用，并在ACP粉末表面形成一层硬脂酸增水层，通过红外谱图、热分析和X射线衍射等研究了表面改性对ACP稳定性的影响。发现采用乙醇回流法不会引起ACP的相转变，
改性ACP粉末可存放超过一年而不发生晶相转变，这表明硬脂酸可以增强ACP的稳定性关键词：无定形磷酸钙；表面改性；硬脂酸：稳定性
中图分类号：TP174；R318
文献标识码：A
SurfaceModification of Amorphous Calcium Phosphates by Stearic Acid and Their Stability
LI Yan-Bao'2, LI Huai-Dong', CHENG Xin', LIU Wen-Hao', LI Dong-Xu', XU Zhong-Zi
(1. State Key Laboratory of Materials-Oriented Chemical Engineering, College of Materials Science and Engineering, Nanjing University of Technology, Nanjing 210009, China; 2. Jiangsu Provincial Key Laboratory of Biomaterials and Biodevices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China)
Abstract: The precipitated amorphous calcium phosphates (ACP) were modified by stearic acid (SA) at a-bout 78°C for different times, using ethanol as reaction medium in a reflux setup. Modification effects of SA were investigated by activation ralio, contact angle, FTIR and TGA/DTA. The stability of the ACP powders before and after modification was examined by FTIR, XRD and TCA/DTA. The results show that the optimal adding amount of SA is 5 wt%,there are about 4 wt% SA on the surface of the ACP powders,and SA reacts with ACP to form —COOCa and HPO2~ groups which leads to a hydrophobic coating form on the ACP surface containing the long alkyl chain of SA. The ethanol mediated reflux method does not induce phase conversion of ACP at about 78°C for 24h, and the modified ACP powders are still amorphous even after stored in air at room temperature for more than one year. It is proposed that SA existing on the surface of the ACP powders has higher ability to retard conversion of ACP into its crystalline polymorphous than β-CD due to the strong steric hindrance of the long alkyl chain of SA.
Key words: amorphous calcium phosphates; surface modification; stearic acid; stability
无定形磷酸钙（amorphouscalciumphosphates，简称ACP）是骨矿化过程初期形成的一个过渡相，也是湿化学法合成磷灰石时形成的一种先驱体[]，ACP 具有优异的生物性能，尤其是生物活性与生物降解性能而广泛地应用于硬组织修复领域，其突出优点是可以根据合成条件有效控制其Ca/P比，以便获得合适的理化性能")，最近有学者将ACP用于生物降
收稿日期：基金项目：
作者简介：
解聚合物的填充，以中和后者在降解过程中产生的酸性降解产物，减轻甚基至解决其植入体内后发生的无菌性炎症反应(23)，然而，ACP/聚合物复合材料界面状况不佳导致复合材料的力学性能大幅下降(3) 采用表面改性可以有效改变复合材料的相界面，提高后者的力学性能(4)，另外，ACP还是一个在长时间内释放药物的药物载体，若对ACP的表面进行改
2008-10-17，收到修改璃日期：2
2009-02-23
国家自然科学基金（50802042）；江苏省自然科学基金（BK2008379）；南京市医学科技发展重点基金（ZKX07016）；江苏省生物材料与器件重点实验室开放基金
率延报（1975），男，博士，副教授，E-mail：ybli@njut.edu.cn，lyanbao@163.com
万方数据